There is also one shaft whose one end is connected to the motor and the other end is connected to the head. EMULSIFIER. 'i:z\On endstream endobj 159 0 obj << /Type /XObject /Subtype /Image /Width 597 /Height 601 /BitsPerComponent 8 /ColorSpace 150 0 R /Length 48396 /Filter /DCTDecode >> stream dispersion of Active Pharmaceutical Ingredients (API) is essential for creating the right In response to the rigors of the pharmaceutical market, there is an increasing need for hygienic construction in process equipment. The manufacturing process is centered around two of the most difficult mixing tasks: hydration of thickening and suspending agents and preparation of a stable emulsion. Recirculation method This is the most common way of using an In-Line mixer, providing a higher degree of homogenization and particle size reduction. 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Shampoos are a mixture of surfactants, conditioning agents and many other ingredients in an aqueous base. Instant access to millions of ebooks, audiobooks, magazines, podcasts and more. high sh&&r mixing t^xperListi Stage 1 The high speed rotation of the rotor blades within the precision machined mixing workhead exerts a powerful suction, drawing liquid and solid materials into the rotor/stator assembly. : How to Move Forward When We're Divided (About Basically Everything), High Conflict: Why We Get Trapped and How We Get Out, World War C: Lessons from the Covid-19 Pandemic and How to Prepare for the Next One, Love Lockdown: Dating, Sex, and Marriage in America's Prisons, The First Ten Years: Two Sides of the Same Love Story, Hunt, Gather, Parent: What Ancient Cultures Can Teach Us About the Lost Art of Raising Happy, Helpful Little Humans, An Anatomy of Pain: How the Body and the Mind Experience and Endure Physical Suffering. WORKING OF SILVERSON bodies. [Paperwork] Mixing - Pharmaceutical Engineering, [Power Point] Mixing - Pharmaceutical Engineering. For low to medium viscosities, we recommend a Batch mixer for smaller volumes. Processing must be carried out under a hygienic environment. Cough mixtures are typically formulated as a syrup at 60 to 75 percent concentration, made from sucrose, maltodextrin, glucose, invert syrup, etc. Silverson Mixer Homogenizers are fast and efficient. Alpha-amylase inhibitors: alternative approach for the treatment of type 2 di Nanocarrier based strategies for eye cancer management and, Nanocarriers role in eye cancer treatment and management, Be A Great Product Leader (Amplify, Oct 2019), Trillion Dollar Coach Book (Bill Campbell). Pharmaceutical cream or ointment is used as a means of delivering an active ingredient directly to the required area of the skin. For more information on this application, read the report here. For more information on this application, please read the report here. 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These units are of robust and simple construction, which ensures that maintenance is easy and downtime minimal. PRESENTED BY RAJDEEPA KUNDU Find Yourself First. As a result bigger globules rapidly break into smaller globules. It consists of an emulsifier head. Manufacture of pharmaceutical creams and ointments presents a number of challenges; a Silverson mixer can rapidly disperse solids into liquids, hydrate thickening and stabilising agents, break down agglomerates and finely reduce particle and globule size to form stable emulsions and suspensions. Vaccines typically consist of an active ingredient suspended in a mixture of proteins and other organic compounds in a liquid base, usually water (wfi water for injection). - Creates stable emulsions and suspensions. The liquids are sucked Through the fine hole. Learn How to Disperse Guar Gum using a Silverson Mixer. Silverson experts understand the mixing challenges you face in the cosmetics industry, such as reducing production times, process hygiene, powder/liquid mixing, producing stable emulsions, dissolving powders, disintegrating solids, blending liquids of different viscosities and dispersing and hydrating gums, diluting high active surfactants, thickeners and stabilisers. Suitable for products such as sauces and flavor emulsions, Silverson in-tank and in-line mixer homogenizers can produce a fine droplet or particle size, typically in the range of 2 to 5 microns; the work head generates high shear rates in a 3-stage process. They are used to get a fine droplet or particle size (2-5 microns). Homogenizers are used to convert coarse emulsion to fine emulsion, used in the Silverson Emulsifier mixer. Lipsticks consist of a pigment dispersed into a mixture of oils and waxes; other ingredients include emollients, pigment dispersants, preservatives and fragrances. These mixing problems can be overcome with the use of a Silverson high shear mixer. Gel toothpastes can be manufactured using a Silverson mixer, and several stages of white toothpaste manufacture can also benefit from high shear mixing. It is also completely aeration-free. This enables any machine to mix, emulsify, homogenize, solubilize, suspend, disperse and disintegrate solids. - Self pumping. It is used for the preparation of creams, ointments, pharmaceutical suspensions, and emulsions of fine particle size. Activate your 30 day free trialto continue reading. SlideShare uses cookies to improve functionality and performance, and to provide you with relevant advertising. For larger batches, a Silverson In-Line mixer recirculating the contents of the vessel will In small vessels this will ensure adequate in-tank movement but in larger vessels an auxiliary in-tank mixer or agitator will be required. u:6aQT'rwr UxBF5W&g#x*y(`YN wtR+$3aKs1^24~n; -'tg3 =[A%D12L! Silverson In-Line mixers are widely used for this application. To find out more about this application, please read the report here. Clipping is a handy way to collect important slides you want to go back to later. A Silverson high shear mixer can rapidly dissolve salts and active ingredients and can hydrate stabilising agents in a fraction of the time taken by conventional mixers, and offers the highest standards of hygienic construction available. - Accelerates reactions. Interchangeable workheads Single stage rotor/stator configurations as standard. They are also more resistant to microbiological attack and contain fewer impurities than conventional surfactants. When you choose a Silverson mixer, you not only get the best quality high shear mixer on the market today, but you also get the advantage of Silversons engineering expertise and years of application knowledge. See our User Agreement and Privacy Policy. When demand outstrips food packaging capacity, new equipment is the best solution. Onsite Engineering assistance available in Northern New Jersey, the lower counties of New York and Connecticut, NYC and Long Island. ABB Urges Greater Adoption of High-efficiency Motors and Drives. Our standard mixers offer a high level of sanitary construction and for more advanced requirements we offer a range of specially designed Ultra Sanitary mixers and have the flexibility and capability to custom build equipment where required to meet your exact mixing requirements. When processing products under sterile or clean room conditions for example injectables and vaccines there are different challenges, especially regarding product sterilisation. These ingredients are supplied in granulated or powder form for dispersion in aqueous or organic solvents at concentrations varying from 10 to 20 percent depending on the desired properties and formula. Silverson has pioneered the concept of Ultra Sanitary mixing equipment and has developed a range of Ultra Sanitary mixers designed for CIP and SIP, suitable for pharmaceutical and biotechnology applications, including processing of sterile ingredients. For more information about this application, please read the report here. High active surfactants with a concentration of 65 to 70 percent offer economies in transport and storage costs. Interchangeable workheads Available to adapt the machine for varying processes. We designed thePharmacyscope.comwebsite with the user in mind. Chesham With a Silverson high shear mixer the ingredients are quickly dissolved and dispersed, resulting in a uniform dispersion in a fraction of the time taken by conventional mixers. Changing from one head hut i ur mtxurs, hut t ur rust tli~s Silversons new UHS-HV Series of In-Line Mixers are designed for processing higher viscosity products. The oil is reduced into the globules quickly resulting in a homogeneous, uniform product. Silverson Machines specializes in the design and construction of high quality, high shear mixers for the processing and manufacturing industries worldwide. Motors TEFC (Totally Enclosed Fan Cooled) washdown duty and NEMA explosion proof rated motors are available as standard. C'4':eTMX| )Bc YvwF n!BC01GaZarXy`$4$>= A Silverson high shear mixer can produce 66 percent sucrose syrup at ambient temperature, offering considerable savings in process time and energy costs. 4j3*WUSz';y3eCZxolm}H!wg6Qy$@w=V RQosW0b*rO#\W endstream endobj 162 0 obj 437 endobj 148 0 obj << /Type /Page /Parent 143 0 R /Resources 149 0 R /Contents 151 0 R /MediaBox [ 0 0 595 842 ] /CropBox [ 0 0 595 842 ] /Rotate 0 >> endobj 149 0 obj << /ProcSet [ /PDF /Text /ImageC ] /Font << /F1 154 0 R /F2 155 0 R >> /XObject << /Im1 159 0 R >> /ExtGState << /GS1 157 0 R /GS2 160 0 R >> /ColorSpace << /Cs5 150 0 R /Cs9 156 0 R >> >> endobj 150 0 obj [ /CalRGB << /WhitePoint [ 0.9505 1 1.089 ] /Gamma [ 2.22221 2.22221 2.22221 ] /Matrix [ 0.4124 0.2126 0.0193 0.3576 0.71519 0.1192 0.1805 0.0722 0.9505 ] >> ] endobj 151 0 obj << /Length 786 /Filter /FlateDecode >> stream Then fine emulsion emerges through the opening of the cover. Waterside The exceptionally rapid Silverson mixing action substantially reduces process times compared with conventional agitators and mixers, and can reduce mixing times up to 90 percent. Motors and Drives Come Together for Motion Efficiency, Performance, Reliability. They offer all the advantages of the standard UHS range but incorporate a unique and innovative pumping rotor design which substantially increases the mixers selfpumping capacity. A Silverson In-Line mixer has the capability to rapidly blend the water and surfactant, either on a batch or continuous basis. Enjoy access to millions of ebooks, audiobooks, magazines, and more from Scribd. Pharmaceutical tablet coatings generally consist of a sugar or cellulose based binder, plasticiser, film-forming agent and colorant. Since 1989, Scott Process Equipment has helped customers in the Bio-Pharm, Pharmaceutical, Chemical, Food & Beverage, Industrial, Personal Care, Cosmetic, Plastic and Polymer industry solve design problems. Waterside For more information about this specialised application, please read the report here. But when product viscosities vary and flavors are superb, not just any machinery will do. `vNCf"u3Wl=)@Z(4*hqSfVO}e4YZ8;U For more information on this application, please read the report here. Now customize the name of a clipboard to store your clips. Scott Process Equipment Corp offers a robust product line, proudly representing pump, mixer, homogenizer, powder blender, sensor, controller, scale, valve, filling system, polymer test equipment, strainer, and heat transfer equipment manufacturers. Although the formulations differ they share many common ingredients. The action of any Silverson In-Line mixer can be modified with the use of rapidly interchangeable workheads. Silverson has been a pioneer in the design and manufacture of a new generation of Ultra Sanitary mixing equipment specifically aimed at the pharmaceutical and biotechnology industries. For those applications which require greater shear, high shnnr mixing expertise? viscosities mixes, a High Shear Bottom Entry mixer with scraper/stirrer to maintain %PDF-1.3 % See our Privacy Policy and User Agreement for details. to 5 m. When making a pharmaceutical cream or ointment a fine, stable emulsion with good Ce1ufqsQhrj2~Ia0{L=@z=;oX8xx!2hanqM)ege@o6 :7nUR'vh;-cV5A0feJJi$p'#D/9.z? p,V@=nc5 Suntan lotions are formulated on similar base ingredients but include UV filters such as titanium dioxide and zinc oxide. Products can be either a water-in-oil (w/o) or oil-in-water (o/w) emulsion, consisting of waxes, emollients and lubricants dispersed in an oil phase, and a water phase containing emulsifying, stabilising and thickening agents, preservatives and in some cases, colorant. As a pioneer in the field of Ultra Sanitary mixing equipment Silverson has an extensive knowledge of the challenges involved in the manufacture of vaccines, injectables and other biotechnology applications. The remainder is made up of thickening agents, stabilisers and active ingredients. - Easy maintenance. To learn more about this application, please read the report here. Some of these ingredients can form agglomerates which conventional agitators cannot readily break down. 2022 PMMI Media Group. 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